PLATELETS AND THROMBOPOIESIS Brief report Persons with Quebec platelet disorder have a tandem duplication of PLAU, the urokinase plasminogen activator gene
نویسندگان
چکیده
1Genetics and Genome Biology, Hospital for Sick Children, Toronto, ON; 2Dalla Lana School of Public Health and Institute of Medical Sciences, University of Toronto, Toronto, ON; 3Molecular Genetics, University of Toronto, Toronto, ON; 4Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON; 5Hematology/Oncology, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC; and 6Department of Medicine, McMaster University, Hamilton, ON
منابع مشابه
PLATELETS AND THROMBOPOIESIS Increased expression of urokinase plasminogen activator in Quebec platelet disorder is linked to megakaryocyte differentiation
Quebec platelet disorder (QPD) is an inherited bleeding disorder associated with increased urokinase plasminogen activator (uPA) in platelets but not in plasma, intraplatelet plasmin generation, and -granule protein degradation. These abnormalities led us to investigate uPA expression by QPD CD34 progenitors, cultured megakaryocytes, and platelets, and whether uPA was stored in QPD -granules. A...
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تاریخ انتشار 2010